Scatter Plot from Scientific Research

Distribution of total cortical surface area and thickness for carriers and non-carriers of S-LoFs in autism-associated or constrained genes (left). The values shown were corrected for age, sex and scanning site. Gene symbols are indicated for individuals with surface area or thickness values over 2 standard deviations from the mean ( z -scored values <-2 or >2) and carrying S-LoFs in autism-associated genes. Standardized values associated with variant presence and autism PGS from multivariable regression analyses of brain anatomy among UK Biobank undiagnosed individuals (right). Error bars correspond to 95% CI. Total values for cortical thickness, surface area and volume were measured as the sum of all 68 regions ( Methods ). S-LoFs in autism-associated and constrained genes were grouped to increase sample size (Supplementary Table 7 shows complete results). P values were corrected for multiple testing using the FDR method.

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