Scatter Plot from Scientific Research

OR (logistic regressions) and standardized values (linear regressions) associated with variant presence and autism PGS from multivariable regression analyses of socioeconomic traits and fluid intelligence, stratified by gene type and autism OR of genes carrying the variants ( Methods ). The Townsend index measures were reversed so that higher material deprivation was indicated with a negative sign. The values associated with autism PGS when S-LoFs in constrained genes with autism OR > 10 are considered in the regression analysis are shown (Supplementary Tables 4 and 5 show complete results). Error bars correspond to 95% CI. P values associated with each value were corrected for multiple testing using the FDR method (full circles correspond to corrected P < 0.05). The number of individuals used in the regression analyses was as follows: fluid intelligence, n = 112,614; income, n = 162,968; qualification, n = 156,483; and Townsend deprivation index, n = 188,630.

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