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AEF0117 (1 mg) significantly decreased positive subjective ratings of cannabis measured by VAS (0–100 mm). a, d, Intoxication subscale comprising the arithmetic mean of the ratings of the ‘I feel a Good Effect’ and ‘I feel High’ items. Rating of the ‘Felt Good Cannabis Effect’ (b, e) and of the ‘Cannabis Cigarette Liking’ (c, f) items. a–c, MMRM global crossover analysis (n = 13 per dose) shows a significant effect of treatment for (Treatment x Time, P = 0.0036 and Dose x Treatment x Time, P = 0.0017) (a) and (Treatment x Dose x Time, P = 0.0034) (b). Significant Treatment x Sequence interactions were found for all the outcomes, P = 0.0182 (a), P < 0.0001 (b) and P = 0.0318 (c).

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