Donor and sample composition in the HLCA core for demographic and anatomical variables. Donors/samples without annotation are shown as not available (NA; gray bars) for each variable. For the anatomical region CCF score, 0 represents the most proximal part of the lung and airways (nose) and 1 represents the most distal (distal parenchyma). Donors show diversity in ethnicity (harmonized metadata proportions: 65% European, 14% African, 2% admixed American, 2% mixed, 2% Asian, 0.4% Pacific Islander and 14% unannotated; see Methods ), smoking status (52% never, 16% former, 15% active and 17% NA), sex (60% male and 40% female), age (ranging from 10-76 years) and BMI (20-49; 30% NA).
