Ratio between the number of individuals with compound heterozygous events and the expected number of individuals given the number of variants, per gene. Missense ( n = 14,336 genes) and synonymous ( n = 9,816 genes) events are shown in addition to LoF events ( n = 2,150 genes) as a comparison. The length of the box corresponds to the interquartile range (IQR) with the center line and values corresponding to the median, and the upper and lower whiskers represent the largest or lowest value no further than 1.5 IQR from the third and first quartile, respectively. P values between categories correspond to two-sided Wilcoxon test P values.
