Heatmap of differentially expressed genes in CADM1 -mutant cells. Heatmap of differentially expressed genes in H295R cells transduced with EV, WT (442- and 453-amino acid isoforms), mutant CADM1 (V380D and G379D in both isoforms) or untransduced (UT). The columns represent different conditions (in triplicates) in the transduction experiments as labeled in b . Each row represents a gene whose mean expression was either upregulated >1.5-fold or downregulated <0.7-fold in variant transduced cells, compared to WT (two-sided one-way ANOVA P < 0.001). Centroid clustering was performed using cluster 3. Yellow represents upregulation and blue represents downregulation of genes as specified by color bar in b . The full heatmap is provided as Source Data Fig. 6 .
