Zoomed image of heatmap in a displaying top 36 genes and clusters including genes associated with biological rhythms process and GJA1. The top 36 genes were differentially regulated whether unstimulated (left half of heatmap) or stimulated by Ang II (right half, 10 nM for 24 h). However, for genes associated with biological rhythms (highlight by bracket with arrow), the differential regulation was more apparent when the transduced cells were stimulated by Ang II. To note, transduction of H295R cells with both G379D and V380D mutant CADM1 substantially increased GJA1 mRNA expression in both isoforms. Genes of interest that are mentioned in the main text are arrowed.
