Illustration from Scientific Research

Change in angle of the TM helix in mutant CADM1 can result in shorter α-CTF. Schematic diagram showing that the fixed distance that ADAM10 cleaves CADM1 from the cell membrane (dashed blue line with scissors) and an increase in the angle of the TM helix in mutant CADM1 could result in a shorter length of cleaved α-CTF.

DOI