Illustration from Scientific Research

ADAM10/γ-secretase-mediated cleavage of CADM1. Schematic representation of the CADM1 protein. Ectodomain shedding due to cleavage by proteases can result in the formation of intracellular CTF and secreted NTF. Cleavage by the protease ADAM10 after the O-glycosylation site leads to the formation of α-CTF (blue scissors), whereas cleavage before the O-glycosylation site leads to β-CTF. The CTF can undergo further cleavage by γ-secretase (purple scissors) to release an intracellular domain. Glycosylation sites (N- and O-) are shown in brown. The 4.1- and PDZ-binding motifs are shown in orange and blue, respectively. Ig, Immunoglobulin domain. Schematic adapted from refs. 19 , 35 .

DOI