Lateral (top) and dorsal (middle) views of the outer portion of the skull proper transparently overlaid on cranial base interior view from a WT mouse, with landmarks on the skull (top and middle) and mandible (bottom) in yellow, and interior landmarks on the cranial base in turquoise. Smaller and larger interlandmark distances (blue and green, respectively) in WT relative to Dp16 or Dp16 2xIfnrs calculated by EDMA. Number of animals—WT ( n = 7, 2 male and 5 female), Dp16 ( n = 7, 4 male and 3 female) and Dp16 2xIfnrs ( n = 6, 4 male and 2 female), followed by bootstrapping 10,000 times. Turquoise—distances different in WT relative to Dp16 rescued in Dp16 2xIfnrs . Red—distances with no difference in WT relative to Dp16 but different in Dp16 2xIfnrs .
