Scatter plots comparing mRNA fold-changes for Dp16 DEGs in heart tissue from mice at the indicated ages for Dp16/WT and Dp16 2xIfnrs /WT, with Ifnrs highlighted in red, Dp16 triplicated genes in blue, nontriplicated Dp16 DEGs in gray and slope ( m ) colored accordingly; solid gray lines represent linear fits for the nontriplicated Dp16 DEGs. Number of animals—E12.5 hearts WT ( n = 6, 2 male and 4 female), Dp16 ( n = 6, 3 male and 3 female) and Dp16 2xIfnrs ( n = 6, 5 male and 1 female); E18.5 hearts WT ( n = 6, 4 male and 2 female), Dp16 ( n = 6, 3 male and 3 female) and adult hearts WT ( n = 5, 2 male and 3 female), Dp16 ( n = 6, 3 male and 3 female) and Dp16 2xIfnrs ( n = 5, 3 male and 2 female).
