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gMFI relative to WT, as measured by flow cytometry, for phosphorylated STAT1 in WBCs at baseline or after 30 min stimulation with IFN-α or IFN-γ. Number of animals—unstimulated WT ( n = 25, 16 male and 9 female), Dp16 ( n = 15, 7 male and 8 female) and Dp16 2xIfnrs ( n = 8, 8 male); +IFN-α WT ( n = 23, 14 male and 9 female), Dp16 ( n = 12, 3 male and 9 female) and Dp16 2xIfnrs ( n = 9, 9 male); +IFN-γ WT ( n = 25, 16 male and 9 female), Dp16 ( n = 12, 12 male) and Dp16 2xIfnrs ( n = 7, 7 male). Significance determined by two-sided Mann–Whitney test.
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