PheWAS for the GPS with (b) or without (c) the HLA region, based on joint meta-analysis of eMERGE-III (n = 102,138) and UKBB (n = 488,377) datasets. The x axis indicates electronic health record phenotypes (phecodes) grouped by system and sorted by significance. The y axis indicates the level of statistical significance expressed as -log10(P value). All P values are two-sided and correspond to a fixed effects meta-analysis of both datasets without correction for multiple testing. Dashed horizontal line represents the significance threshold after Bonferroni correction for the number of phenotypes; significant associations are labeled. An upward triangle indicates a positive association (increased risk) and a downward triangle indicates a negative association (decreased risk) with increasing GPS.
