Heatmap from Scientific Research

Intersection with TF ChIP-seq peaks with the significant (top) and suggestive (bottom) IgAN risk loci. The x axis shows IgAN risk loci. The y axis shows top significant TFs ranked by the number of intersecting loci. A colored box at the intersection indicates that a given locus has at least one IgAN-associated variant located within a ChIP-seq peak for the given TF. Datasets were considered significant if their RELI empirical P values corrected for multiple testing were <1 x 10 -4. TFs binding to EBNA2 super-enhancers are colored in red; ChIP-seq dataset cell types are indicated in parentheses. Related cell lines for a given TF (for example, GM12878 and GM12891) were merged for clarity. I-κB, inhibitor of nuclear factor kappa B.

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