Bar Plot from Scientific Research

Cell-type-specific heritability enrichment for functional annotations based on FUN-LDA scoring system for all ENCODE and Roadmap Epigenomics cell types and tissues. The x axis depicts -log 10 of two-sided P values for heritability enrichment without multiple testing correction with only significant results grouped by the tissue type depicted. Solid red line represents the Bonferroni-corrected significance threshold ( P = 3.9 x 10 -4 ). Dashed black line represents the -log 10 of the nominal uncorrected P value ( P = 0.05). The most significant heritability enrichments were found in blood immune cells and gastrointestinal tissues.

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