Manhattan Plot from Scientific Research

Manhattan plot for the combined meta-analysis across 38,897 individuals. The dashed horizontal line indicates a genome-wide significant P value = 5.0 x 10 -8. The y axis shows -log 10 of two-sided P values (fixed-effects meta-analysis of all cohorts without correcting for multiple testing) and is truncated to accommodate the HLA signal. The x axis shows genomic position for each chromosome (1-22 and X). Red, new genome-wide significant loci associated with IgAN; dark blue, previously known loci reaching genome-wide significance in this study. Locus name based on the top candidate gene from our biological prioritization strategy.

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