Scatter Plot from Scientific Research

Effect size (beta, y axis) as a function of MAF (x axis) for suggestive and significant GWAS loci. Minor alleles with positive effect sizes (risk alleles) are represented at the top, and negative effect sizes (protective alleles) are represented at the bottom. A three-degree polynomial regression curve was fitted to illustrate positive and negative correlations. Correlation coefficients (R) and their corresponding P values (P) are also provided. Light-blue circles represent genome-wide significant loci and are labeled using the most likely candidate gene per locus. Blue triangles represent suggestive loci.

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