Scatter Plot from Scientific Research

GASPACHO framework. Expression data and relevant metadata (known confounding factors) as well as donor (cell line) structure are used to construct a GPLVM to extract the target cell state, while dissecting cell cycle effect and other known and unknown technical variability including donordonor variation. The result of the GPLVM is then utilized for the subsequent analyses of spatial DE analysis using a GP mixture model and the genetic association mapping using a GP regression model ( Methods ). Cond, experimental condition; Dim, dimension; ref/het/alt, reference homozygote/heterozygote/alternative homozygote.

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