Workflow from Scientific Research

Variable S represents experimental covariates, such as batch or experimental condition. Each data modality is encoded into modality-independent latent representations (using neural network encoders) and then, these representations are merged into a joint latent space. The joint latent representation is used to estimate (decode) the input data together with chromatin region-specific effects ( r A ), gene-specific dispersion ( σ R ), cell-specific effects ( ℓ A , ℓ R ), accessibility probability estimates ( Y Z ) and mean gene expression values ( μ R ).

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