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Construction of SELECTIV mice that allow Cre-mediated overexpression of the mouse AAV receptor ( Aavr ). The construct contains the CAG promoter followed by the loxP-STOP-loxP sequence, a strong transcription stop sequence that can be removed by Cre recombination. It encodes the mouse Aavr fused to mCherry and spCas9 after an F2A self-cleaving peptide sequence. This cassette was inserted into the C57BL/6 mouse genome using targeted integration in the H11 locus. SELECTIV mice can be crossed with mice expressing Cre recombinase under specific promoters to produce mice with cell-type- or tissue-specific overexpression of Aavr .

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