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Transduction of MEFs overexpressing AAVR. MEFs were generated from embryos from a SELECTIV-WB and WT mouse breeding (individual derived MEFS, control n = 4; SELECTIV-WB n = 6 for AAV2, AAV8 and AAV9, and n = 5 for AAV4). MEFs were transduced with AAV2-, AAV4-, AAV8- and AAV9-luciferase. Transduction was assessed by luciferase activity 48 h later. Mean value and s.e.m. are shown. Fold-changes are indicated, and the P value was calculated using a two-way analysis of variance (ANOVA) with Holm–Šídák’s multiple comparisons test, where **** P < 0.0001; NS, not significant (AAV2 P = 1.6 × 10 −12 , AAV4 P = 0.65, AAV8 P < 1 × 10 −15 , AAV9 P < 1 × 10 −15 ).

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