Heatmap from Scientific Research

Interaction complexity: simple interactions involve only a few genomic regions, while complex interactions involve many genomic regions at once. In Hi-C, ligation events connect two pieces of DNA; therefore, pairwise contacts can be directly determined while measurement of higher-order contacts may be affected by competing ligation events resulting in dilution effects (1, arrow). Co-segregation determined through GAM is not affected by the number of elements (2).

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