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Schematic for detecting feature pair enrichments in GAM- or Hi-C-specific contacts (red and blue, respectively). Each contact is defined by two genomic anchor points that we categorized as either positive or negative for peaks of the respective feature (1). We assessed 105 feature pairs (2) and quantified feature occurrences at the anchor points, filtering out contacts with no feature pairs (3) to identify most distinctive feature combinations between GAM-specific and Hi-C-specific contacts (4). TF, transcription factor.
#Heatmap#Line Plot#Pie Chart#Workflow#Hi-C#GAM#Feature Pair Enrichment#Contacts#Genomic Anchor Points#Transcription Factor
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