Heatmap from Scientific Research

Strategy to assess differences and similarities between GAM and Hi-C contact maps (chr. 4, 80-90 Mb). GAM and Hi-C contact data have different distributions (1); therefore, contacts at the same genomic distance undergo z -score transformation (2). Hi-C z -scores are then subtracted from GAM z -scores to generate a delta z -score matrix (3), from which we extract the 5% most differential contacts between GAM and Hi-C (GAM-specific or Hi-C-specific; 4) and the top 10% of contacts common for both methods (strong-and-common; 5).

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