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mRNA expression of genes related to bile acid synthesis (WT, n =5; Mdr2 -/-, n =10; WT + DSS, n =7; Mdr2 -/- +DSS, n =12); one-way ANOVA with Bonferroni’s multiple comparison test ( Cyp8b1 : WT vs Mdr2 -/-, 95% CI 0.223–0.827, P = 0.0004; WT vs WT + DSS, 95% CI 0.1056–0.7512, P = 0.0063); Kruskal-Wallis test with Dunn’s multiple comparison test ( Cyp7a1 : WT vs WT + DSS, P= 0.0011; Mdr2 -/- vs Mdr2 -/- +DSS, P = 0.0197; Cyp27a1 : WT vs WT + DSS, P = 0.0008; Mdr2 -/- vs Mdr2 -/- +DSS, P = 0.0018).
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