TBOA reduces the number of response failures during a pulse train. Individual epsc peak response amplitudes for 6 cone to bipolar cell pairs (3 cb1 and 3 cb3), before, during, and after TBOA application, were each normalized to the average response in TBOA (center black diamonds) and combined. BC silhouettes republished from Light, A. C. et al. Organizational motifs for ground squirrel cone bipolar cells. J Comp Neurol 520, 2864-2887 (2012). Cone silhouette republished from Neuron, Vol 91, Grabner, C. P. et al. Mechanism of High-Frequency Signaling at a Depressing Ribbon Synapse, 133-145, (2016), with permission from Elsevier.
