Plots of I 50 for individual cb1 and cb3 cells. AMPA receptors were blocked with 35 uM GYKI 53655 in all experiments. Cb3a cell I 50 = 0.18 ± 0.02 mW (mean ± S.E.; n = 6 independently recorded bipolar cells); cb1a cell I 50 = 1.06 ± 0.17 mW; ( n = 7 independent recordings; significantly different, p = 0.0002; two-tailed unpaired t test). Cb1a ( n = 7) and cb1b (I 50 = 0.98 ± 0.11 mW; n = 3) cell I 50 values were not significantly different ( p = 0.5082, two-tailed unpaired t test). BC silhouettes republished from Light, A. C. et al. Organizational motifs for ground squirrel cone bipolar cells. J Comp Neurol 520, 2864-2887 (2012). Cone silhouette republished from Neuron, Vol 91, Grabner, C. P. et al. Mechanism of High-Frequency Signaling at a Depressing Ribbon Synapse, 133-145, (2016), with permission from Elsevier.
