Pathway from Scientific Research

The signaling network was reconstructed using PHONEMeS, and the Akt1 subnetworks were extracted by selecting 3-step downstream nodes of Akt1. The node fill color corresponds to the protein activity inferred by PHONEMeS, with yellow and gray marking up- and downregulated activity, respectively. The border color corresponds to the cluster (fC1-fC4) in which a kinase was predominantly overrepresented based on the lowest P -value. The node size corresponds to the number of outgoing edges. Source data are provided as a Source data file.

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