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Multiple sequence alignment of selected insect and mammalian PARP automodification domain sequences. Ser-ADPr sites identified in d Parp and h PARP1 are indicated above the alignment by double-dagger (?) and koppa (?) symbol, respectively. Indexing indicates d Parp residue position. Extended insect alignment is provided in Supplementary Fig. 2 and sequences in Supplementary Table 1 .

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