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The positive feedback loop that drives the progression of the disease. Based on our delayed correlation results of host-microbiome gene expression, we found metabolic activities present in positive and negative lags. Based on these common activities, we present the infinite loop of reciprocally reinforced interactions between a dysbiotic microbiome and the host that caused the progression of the disease in red metabolic activities that were activated (enriched) and in blue metabolic activities that were repressed

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