Protein Structure from Scientific Research

Superimposition of PCO371–PTH1R–G s , isoproterenol–β 1 adrenaline receptor (β 1 AR)–G s and formoterol–β 1 AR–β-arrestin complexes, aligned on TM2–TM5. Black arrows indicate the hallmark conformational changes of TM5 and TM6 in G s -bound and β-arrestin-bound structures (left). PCO371 clashes with TM6 in the dashed circle (centre and right).

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