Protein Structure from Scientific Research

Superimposed structures of PTH-bound PTH1R, PCO371-bound PTH1R, inactive or inactive-like class B1 GPCRs (PTH1R, GCGR, GLP-1R and CRF1R), and all other structures of endogenous agonist-bound class B1 GPCR (PTH2R, SCTR, GHRHR, PAC1R, VIP1R, VIP2R, GCGR, GIPR, GLP-1R, GLP-2R, CALCR, CALRL, CRF1R and CRF2R). The angle is shown among the C atoms of Ile/Met/Val 6.54 , Gly 6.50 , and Val/Ala/Leu 6.39 residues in TM6. Note that the angle of PCO371-bound PTH1R is calculated among Leu 6.39 , Pro 6.47 and Ile 6.54 owing to the kink at Pro 6.47 .

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