Line Plot from Scientific Research

Fit of empirical p values to the BBUM model. Plotted for each dataset are empirical cumulative distributions of p values for upregulated miRNAs (turquoise) and downregulated miRNAs (orange), with the respective cumulative distributions of the fitted BBUM model overlaid as smooth lines. The uniform null distribution is shown as a gray dashed line. Deviation between the distribution for downregulated miRNAs and the null distribution is shaded in light orange; a greater deviation at the lower tail indicates a greater excess in density near p = 0, which corresponds to a more substantial contribution of the beta component for secondary effects in the BBUM model

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