Clinical features and molecular alterations of bilateral and familial WT cases. Each column represents one tumor sample. Patients are indicated by alternating black and white boxes in the top row; adjacent boxes of the same color denote bilateral and/or relapse tumors. Familial cases are joined by brackets. 2 nd hit denotes the mechanism of complete inactivation of the predisposing gene. Details can be found in Additional file 1: Tables S2, S3 and Additional file 2: Fig. S2
