Illustration from Scientific Research

Lollipop plot of the splice-altering variants identified by Introme in the ZERO childhood cancer cohort [ 28 ] for genes RB1, made using ProteinPaint [ 29 ]. Each circle represents the location of at least one genetic variant identified as reportable and splice-altering in the ZERO cohort (red: somatic variant, blue: germline variant). Shaded areas on the transcript represent protein domains.

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