Scatter Plot from Scientific Research

The Introme scores and the functional scores calculated for BRCA1 variants assessed using a saturation mutagenesis screen [ 27 ]. Variants with functional scores > - 0.748 are classified as tolerated whilst functional scores < = - 1.328 correspond to non-functional variants, as determined in the original study [ 27 ]. Variants are coloured by their ClinVar pathogenicity classifications (P: pathogenic; LP: likely pathogenic; VUS: variant of uncertain significance; B: benign; LB: likely benign).

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