Sample-wise Pearson correlation of imputed species-tissue combination mean samples with held-out observed values when considering all methylation probes. Individual to individual variability represents the average pairwise correlation of observed data between individuals of the same species and tissue type for each combination. Baselines and individual to individual variability labeled by Wilcoxon signed-rank test p -value comparing CMImpute’s sample-wise Pearson correlation to the individual to individual variability and each baseline’s sample-wise Pearson correlation for each imputed species-tissue combination ([CMImpute, Individual to Individual Variability], [CMImpute, Species Baseline], [CMImpute, Logistic Regression], [CMImpute, Tissue Baseline], [CMImpute, Global Baseline]).