Relationship of the distributions of observed and MPRALegNet-predicted activity scores in HepG2 cells for the subset of elements possessing either zero or one TFBSs corresponding to the NFYA/C or FOXD2 families, or one TFBS for both transcription factor families, adjusted for potential confounding effects induced by the presence of other transcription factors ( Methods ). The red horizontal line is the expected activity score under a multiplicative model. Box centre lines and edges as in Fig. 2 . Whiskers show the most extreme data point up to a maximum of 1.5 the interquartile range.
