Stacked Bar Plot from Scientific Research

The codon positions in Rv0678 that conferred bedaquiline resistance (and borderline resistance) were compared between three datasets: in-vitro selected mutants, which were single clones isolated from in-vitro evolution experiments (appendix 3 [p 1]); in-vitro population sequencing, corresponding to variants detected from deep sequencing of the entire mutant population in in-vitro evolution experiments (appendix 3 [p 2]); and variants in clinical strains from the CRyPTIC project and literature-reported strains (appendix 2). The variant at base-pair position 10 is the variant in the promoter region. In-vitro population sequencing was not quantifiable by number of isolates, hence the negative bar orientation for the affected codon positions.

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