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A subset of antibodies from each enrichment signature group (top panel) was produced and tested for binding to target and nontarget cells (bottom panel). The cross represents the geometric mean of receptor expression on target and nontarget cells. Inset: antibodies in the <100,000 or upregulated group further classified as binding upregulated or restricted low-expressed receptors based on comparative analyses of selections with nontarget cell competition (solid lines) and selections without nontarget cell competition (dotted lines). See alsoFigure S4.
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