The model represents the number of mother-to-child infections that occur in two different scenarios: without HTLV-1 antenatal screening (status quo) and with HTLV-1 antenatal screening, followed by postnatal interventions in women with HTLV-1 infection. In the scenario alternative to the status-quo scenario, a population of pregnant women is screened for HTLV-1 with ELISA. Women with reactive samples are tested by western blot. Women with HTLV-1 infection refrain from breastfeeding. The model considers the effect of the performance of laboratory assays on the number of true positive, true negative, false positive, and false negative results. The risk of HTLV-1 transmission varies according to the duration of breastfeeding and the number of infant infections is linked to the breastfeeding pattern in the country. FN=false negative. FP=false positive. HTLV-1=human T-cell lymphotropic virus type 1. MTCT=mother-to-child transmission. TN=true negative. TP=true positive.
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