Protein Structure from Scientific Research

Locations of the 5 A20, M45, and A50 residues (shown as sticks with yellow backbone) in the structure of the wild-typePlasmodiumproteasome (shown as cartoon), with fitted WLL (cartoon with gray backbone).21,29The table inset shows IC50fold shifts for inhibitors tested against proteasome mutant lines compared with the wild-type parental line. Data for the 5 M45I line were taken from Xie et al.25

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