Chemical structures and binding properties ofPlasmodium-selective and non-selective proteasome inhibitors tested herein. Mean IC50 SEM for inhibitors tested against Dd2 parasites is shown (N = 220, n = 2; seeTable S1). Binding properties (covalent or not, reversible or not) for thePlasmodium-selective inhibitors are described in the following citations: vinyl sulfones,21,23,43epoxyketones,44,45asparagine ethylenediamines (AsnEDAs),13,24the macrocyclic peptide TDI-8304,27and the N,C-capped peptides listed as compounds 4 and 6.20The binding properties and potent antiplasmodial activity of the human proteasome inhibitors epoxomicin and bortezomib have also been previously described.46,47,48,49
