Sequence alignment of TYRsBmTYR (PDB: 3NM8),SinATYR (UniprotKB: L0D705),SaTYR (PDB: 6J2U),ScTYR (PDB: 1WX2),SkTYR (UniprotKB: A0A077HD11), andSzTYR (UniprotKB: A0A2S3Y8X7) with AOsSgGriF (UniprotKB: B1VTI5),SlfevF (UniprotKB: A0A2H5BVB1),SmAO (UniprotKB: A0A1W7D1S4),SmNspF (UniprotKB: D6RTB9),SsAO (UniprotKB: A0A0W7WYA7),ScAO (UniprotKB: A0A1Q4VUB3),SeAO (UniprotKB: A0A197SSE1),SmpAO (UniprotKB: A0A1V2RQ55),SrAO (UnprotKB: A0A2S4YIE3),StbagH (UnprotKB: A0A482LS25),SwAO (UnprotKB: A0A429IXZ5) andSwfevF (UnprotKB: L0N6P7).[29]Letters (dark blue): first, second, and third histidine coordinating copper A center. Letters (shaded in grey): conserved residues present only in AOs. Letters (magenta): conserved asparagine. Letters (orange): conserved tyrosine. Letters (cyan): residues in TYRs homologous to conserved asparagine in AOs.
