Structural alignment of the active center ofSgGriF (AlphaFoldDB model (B1VTI5)) cartooned in green andSzTYR fromStreptomycessp. ZL-24 (AlphaFoldDB model (A0A429IXZ5)) cartooned in dark grey.[30,31]Ile42 inSzTYR is depicted in cyan. Conserved Asn43 inSgGriF is shown in magenta, and conserved Tyr47 inSgGriF is highlighted in orange. Histidines coordinating CuA and CuB are numbered from His1 to His6 starting from N-terminus, and nitrogen atoms are depicted in blue and oxygens in red. Models are taken from AlphaFold DB[30,31]and visualized with the PyMOL Molecular Graphics System, Version 3.0 Schrodinger, LLC.
