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Flow cytometric analysis of IFNγ expression of intratumoral CD8+T cells in untreated and RT-, aCD25-, and PD1-IL2v-treated pancreatic tumor-bearing mice. Gating was performed on live CD45+CD8+cells, n ≥ 6 per group. Mice were orthotopically implanted with PK5L1940 cells. RT was administered 7 days post-implantation. PD1-IL2v and aCD25 were dosed once per week beginning day 7 post-implantation. Serum was collected at time of sacrifice. Tumors were harvested 21 days post-implantation. Data are represented as mean ± SEM. The p values were calculated with Student’s t test,*p < 0.05,**p < 0.01,***p < 0.001,****p < 0.0001. See alsoFigures S1–S3.

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