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Alignment of human and mouse PER1/2 proteins showing conservation of the disordered FASP region flanked by two highly conserved binding motifs (CK1BD-A/B) characterized as PONDR (predictor of natural disordered regions) minima and predicted to be alpha-helices by AlphaFold2. The priming site (S662, human PER2 numbering) is shown, with sequential phosphorylation sites indicated by asterisks.
#Illustration#Table Image#PER1/2 Proteins#FASP Region#CK1BD-A/B Motifs#PONDR#AlphaFold2#Phosphorylation Sites
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