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Schematic representation of the experimental approach. NASH-predisposed monkeys were screened from over 1,000 cynomolgus monkeys. Sixty-nine male monkeys (age ≥ 9 years, BMI > 30) were selected for physical, biochemical, and histological analyses. Twenty NASH-predisposed monkeys with NAFLD activity score (NAS) 1–3 were selected and fed the NASH diet for 10 months. Biochemical, histological, and transcriptional (RNA-seq) indices were assessed before and after feeding the NASH diet for 10 months.

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