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Schematic comparison of mRNA-LNP delivery of S (as in COVID-19 mRNA vaccines) (top) versus delivery of an S-EABR construct (bottom). Both approaches generate S peptides displayed on class I MHC molecules for CD8+T cell recognition and result in presentation of S antigens on cell surfaces. The S-EABR approach also results in budding and release of eVLPs displaying S antigens.

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