Left: scheme depicting the preferential interaction of G3BP1 with unfolded state of RNA. G3BP1-RNA interaction mediates condensate assembly. Middle: schematic of a RNP granule-like condensate assembled from G3BP1 and RNA. Unfolded RNAs inside the condensate form an RNA network mediated through RNA-RNA interactions to inhibit mobility and global translation. Right: DDX3X attenuates RNA-RNA interactions within the condensate and increases RNA mobility to facilitate condensate dissolution and restart of global translation.
